finanzen.net
16.05.2019 18:21
Bewerten
(0)

Blood Test Can Measure Effectiveness of Treatments for Aggressive Skin Cancers

DRUCKEN

NEW YORK, May 16, 2019 /PRNewswire/ -- Blood tests that track the amount of tumor DNA can ? after only one month of drug therapy ? detect how well treatment is working in patients with skin cancer, a new study finds.  

(PRNewsfoto/NYU School of Medicine)

Led by researchers from NYU School of Medicine and Perlmutter Cancer Center, the study takes advantage of the nature of cancer cells, which die and are replaced by new cells continuously as part of aggressive cancer growth. Tumor cells burst as they die, spilling their DNA into the bloodstream, where it can be measured by tests, enabling improved diagnosis and better targeting of treatment based on each individual tumor's DNA.  

For the new study, researchers traced circulating tumor DNA or ctDNA for the cancer gene BRAF, a gene that plays a key role in many melanomas, the most deadly form of skin cancer. In the United States, more than 7,200 individuals are expected to die from metastatic melanoma in 2019, with BRAF mutations playing a role in nearly half of such diagnoses, according to the Skin Cancer Foundation.

"Our study offers firm evidence that tracking this genetic information may be helpful in identifying patients whose cancers shrink and who survive longer as a result of a particular drug regimen," says senior study investigator David Polsky, MD, PhD, the Alfred W. Kopf, MD, Professor of Dermatologic Oncology at NYU Langone Health.

For the study, being presented at the 2019 American Society of Clinical Oncology annual meeting on June 1 in Chicago, researchers analyzed blood samples from 345 male and female patients with stage III or IV melanoma, which had already spread from the skin to other organs, and who had BRAF mutations. 

These patients could not be treated surgically and were part of a larger group of patients participating in a clinical trial of the drugs dabrafenib and trametinib, designed to target BRAF-mutated cancers.

Among the study's key findings was that the tumor's BRAF mutation could be detected by the new blood test in 93 percent of the patients before treatment started. In addition, the research team found that BRAF ctDNA levels were no longer detectable after one month of therapy in the 40 percent of patients who had a positive clinical outcome after targeted therapy (as measured by an average survival time of 28 months). By contrast, the 60 percent of patients who did not respond as well still had detectable ctDNA levels, and survived for an average of just 14 months.

Polsky and his colleagues say this test appears to be more revealing than the current standard test, which measures lactate dehydrogenase (LDH), an enzyme often elevated by melanoma, because fluctuations in LDH often do not accurately predict treatment success or failure.   

The typical method of identifying disease progression for these melanoma patients is through CT scans every three months, but Polsky says the blood test in the current study, noted as the largest BRAF detection rate in patients' blood to date, suggests it may be helpful to doctors because these tests can be done more frequently and efficiently, and results could be available within a few days.

"If further testing proves successful, monitoring blood samples for BRAF could give us an early indication of whether or not we need to adjust a patient's treatment plan," says Polsky, dermatologist and director of the pigmented lesion service at NYU Langone.

Researchers next plan to test the efficacy of monitoring patient blood samples over longer periods of time, such as several months. They also hope to open a clinical trial to determine whether treatment decisions based on these test results improves patient survival.  

Novartis Pharmaceuticals of East Hanover, New Jersey, funded the clinical trial of their drugs, and provided the blood samples and clinical data used in the study, which they also funded. The ctDNA test was developed by Bio-Rad Laboratories in Hercules, California.

Besides Polsky, other NYU Langone researchers include Mahrukh M. Syeda, MS; Jennifer M. Wiggins, PhD; and Broderick Corless, BS. Additional investigators include Georgina V. Long, MD, PhD, at Melanoma Institute Australia, The University of Sydney, and Royal North Shore and Mater Hospitals in Australia; Keith Flaherty, MD, at Dana Farber Cancer Institute in Massachusetts; Dirk Schadendorf, MD, at University Hospital Essen and the German Cancer Consortium in Germany; Paul D. Nathan, MD, at Mount Vernon Cancer Centre in the United Kingdom; Caroline Robert, MD, PhD, at Institut Gustave Roussy and Paris-Sud University in France; Antoni Ribas, MD, PhD, at University of California, Los Angeles; Michael A. Davies, MD, PhD, at MD Anderson Cancer Center in Texas; Jean-Jacques Grob, MD, PhD, at AIX-Marseille University in France; and Eduard Gasal, Matthew Squires, Mahtab Marker, and Jan C. Brase at Novartis based in Switzerland.

Media Inquiries:
Jamie Liptack
212-404-4279
Jamie.liptack@nyulangone.org 

Cision View original content to download multimedia:http://www.prnewswire.com/news-releases/blood-test-can-measure-effectiveness-of-treatments-for-aggressive-skin-cancers-300851775.html

SOURCE NYU Langone Health

Effektiver Vermögensausbau

Mit 12 Wertpapieren langfristig und erfolgreich Vermögen aufzubauen? Wie Sie so erfolgreich investieren, erklärt Börsenprofi Tobias Kramer heute Abend live im Webinar.
Jetzt kostenlos anmelden!
Anzeige
Anzeige
Börse Stuttgart Anlegerclub

Die richtige Strategie für die Börsenkrise

Stecken Sie nicht den Sand in den Kopf, sondern kaufen Sie die richtigen Aktien. Erfahren Sie im aktuellen Anlegermagazin mehr über attraktive Qualitätsaktien und zyklische Aktien
Kostenfrei registrieren und lesen!

Heute im Fokus

DAX klar im Minus -- Bundesbank beurteilt Konjunkturentwicklung skeptisch -- thyssenkrupp-Aufsichtsrat berät neues Konzern-Konzept -- Wirecard, Deutsche Bank, Lufthansa, Infineon im Fokus

QIAGEN-Aktie im Aufwind: US-Zulassung für Molekulartestsystem. Ryanair verdient deutlich weniger. Google schränkt Zusammenarbeit mit Huawei ein. Grand City Properties bleibt auf Wachstumskurs. T-Mobile US und Sprint: Zu weiteren Zugeständnissen bereit.

Die 5 beliebtesten Top-Rankings

Diese Aktien hat Warren Buffett im Depot
Die Änderungen unter den Top-Positionen
Die erfolgreichsten Kinofilme der letzten 25 Jahre
Welche Titel knackten die Milliardenmarke an den Kinokassen?
In diesen Berufen bekommt man das höchste Gehalt
Mit welchem Beruf kommt man am ehesten an die Spitze?
Städte für Millionäre
Hier fühlen sich die Vermögenden am wohlsten
In diesen Ländern ist Netflix am billigsten
Wo zahlen Abonnenten am wenigsten?
mehr Top Rankings

Umfrage

Bundesjustizministerin Barley (SPD) hat vorgeschlagen, die Mietpreisbremse zu verschärfen. Was halten Sie von dieser Idee?

Online Brokerage über finanzen.net

finanzen.net Brokerage
Handeln Sie für nur 5 Euro Orderprovision* pro Trade aus der Informationswelt von finanzen.net!

ETF-Sparplan

Oskar ist der einfache und intelligente ETF-Sparplan. Er übernimmt die ETF-Auswahl, ist steuersmart, transparent und kostengünstig.
Zur klassischen Ansicht wechseln
Kontakt - Impressum - Werben - Pressemehr anzeigen
Top News
Beliebte Suchen
DAX 30
Öl
Euro US-Dollar
Bitcoin
Goldpreis
Meistgesucht
Wirecard AG747206
Huawei TechnologiesHWEI11
Deutsche Bank AG514000
Daimler AG710000
TeslaA1CX3T
BayerBAY001
Amazon906866
Apple Inc.865985
CommerzbankCBK100
NEL ASAA0B733
BASFBASF11
Infineon AG623100
Allianz840400
BMW AG519000
Volkswagen (VW) AG Vz.766403