finanzen.net
19.02.2019 13:00
Bewerten
(0)

Broad Institute launches Gerstner Center for Cancer Diagnostics

CAMBRIDGE, Mass., Feb. 19, 2019 /PRNewswire/ -- The Broad Institute of MIT and Harvard announced today a new $15 million commitment by Louis V. Gerstner, Jr., former CEO and chairman of the board of IBM Corporation, and current chairman of the board of directors of the Broad Institute, to create the Gerstner Center for Cancer Diagnostics at the Broad Institute. The new Center will be endowed with an additional commitment of $10 million by the Eli & Edythe Broad Foundation.

The Gerstner Center aims to advance blood-based biopsies for tracking disease progression and pursue other cancer diagnostics that have the potential to benefit millions of patients worldwide. The new Center builds upon a major effort at Broad focused on elucidating the mechanisms of cancer drug resistance, launched by a $10 millioncommitment from the Gerstner Family Foundation in 2015. This work has already given rise to a major project with IBM Watson Health to understand and prevent cancer progression, supported by $50 million in funding to create and make freely available to the scientific community data about cancer resistance.

While many aspects of cancer treatment have improved substantially over the past decade, diagnostics have lagged. Today, in order for a doctor to monitor a patient's disease progression or response to treatment, they must either obtain a surgical tumor biopsy or send the patient for a CT or MRI scan. These approaches can be costly, invasive, and most importantly, provide no molecular insights.

Blood biopsies have the potential to monitor a patient's response to treatment with molecular precision, with the potential to identify tumor recurrence much earlier than existing tests. As a result, blood biopsy can help patients and doctors determine whether a change in treatment is needed.

"There is a transformation underway in the field of cancer diagnostics," said Eric S. Lander, president and founding director of the Broad Institute. "I am astounded at the progress we have seen in just the last five years—especially in the area of blood biopsies—by researchers here at the Broad and at other institutions. We have the opportunity now to profoundly improve patient care. With Lou's visionary partnership, we can move closer toward making blood biopsy and other diagnostic technologies for tracking disease progression a powerful new standard-of-care for patients."

The Gerstner Center will focus on response-monitoring, that is, tracking how a patient is faring under treatment, whether that is chemotherapy, radiation, or immunotherapy. It will also focus on studying patients with minimal residual disease, which involves identifying small numbers of cancer cells that remain in people who have undergone treatment, and which may result in relapse months to years, or even decades, later. Monitoring either patient response or minimal residual disease using blood biopsy requires greater sensitivity than is currently available, which is why the new Center will focus on these particular areas.

Tracking Tumor DNA

Blood biopsy (also sometimes called liquid biopsy) is a process in which clinicians detect and analyze cancer DNA from a single blood draw.

Cells in the body, including tumor cells, regularly expel fragments of DNA into the bloodstream. With blood biopsies, clinicians collect this "cell-free" DNA from a blood draw and then profile the fragments originating from cancer cells. Tracking this data could make it possible to monitor cancer recurrence, a patient's response to treatment, and other clinically important features—all from blood samples. Much of it can be done in real time.

"Not long ago I thought that blood biopsy was more science fiction than reality," said Todd Golub, Chief Scientific Officer at the Broad Institute, Director of the Cancer Program, and Director of the Gerstner Center. "But thanks to work here at the Broad as well as in many labs across the country, blood biopsy has become a reality. In fact, Broad scientists have demonstrated that it's possible to look at an entire cancer genome from a blood biopsy. That is spectacular." Golub is also the Charles A. Dana Investigator in Human Cancer Genetics at the Dana-Farber Cancer Institute, professor of pediatrics at Harvard Medical School, and a Howard Hughes Medical Institute investigator.

"Using blood biopsy to track patient response will help us not only determine if a tumor has gotten smaller -- something imaging technologies already do -- but will help us understand what is happening to the molecular composition of the tumor, something you can't do with a CT scan or MRI," said Viktor Adalsteinsson, Associate Director of the Gerstner Center and leader of the blood biopsy team in the Broad's Cancer Program. "Having had loved ones battle with cancer, I can say firsthand what potential impact this sort of technology and research could have on patients."

The Gerstner Center will collaborate broadly, working closely with technology innovators, cancer biologists, computational scientists and clinicians. The Center will also pilot other promising new approaches to cancer diagnostics.

"I believe that the Broad Institute is uniquely poised to have a transformative effect in the world of cancer diagnostics," Gerstner said. "The need is great, and I am committed to supporting this partnership to help doctors make the very best treatment decisions for their patients based on a molecular understanding of their progress in real-time. This will make cancer therapies more precise and ultimately far more effective."

About the Broad Institute of MIT and Harvard

Broad Institute of MIT and Harvard was launched in 2004 to empower this generation of creative scientists to transform medicine. The Broad Institute seeks to describe all the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods, and data openly to the entire scientific community.

Founded by MIT, Harvard, Harvard-affiliated hospitals, and the visionary Los Angeles philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff, and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide. For further information about the Broad Institute, go to http://www.broadinstitute.org.

Broad Institute Logo. (PRNewsFoto/Broad Institute)

Cision View original content to download multimedia:http://www.prnewswire.com/news-releases/broad-institute-launches-gerstner-center-for-cancer-diagnostics-300797430.html

SOURCE Broad Institute

Werbung
Werbung
Börse Stuttgart Anlegerclub

Die richtige Strategie für die Börsenkrise

Stecken Sie nicht den Sand in den Kopf, sondern kaufen Sie die richtigen Aktien. Erfahren Sie im aktuellen Anlegermagazin mehr über attraktive Qualitätsaktien und zyklische Aktien
Kostenfrei registrieren und lesen!

Heute im Fokus

DAX zurückhaltend -- Asiens Börsen uneinheitlich -- Fed betont Unsicherheit durch Handelskonflikte -- OSRAM hebt Stillhalteabkommen mit ams auf -- Regierungskrise in Italien -- EVOTEC im Fokus

Eckert & Ziegler-Aktie im Fokus: Besser als zu Nemax-Zeiten. Nordamerika-Geschäft gibt JOST Werke Auftrieb. thyssenkrupp klagt gegen EU-Verbot von Stahl-Joint-Venture mit Tata. CTS Eventim verkauft mehr Online-Tickets und steigert Betriebsgewinn. E.ON begibt grüne Anleihen in Milliardenhöhe.

Die 5 beliebtesten Top-Rankings


Diese Aktien hat Warren Buffett im Depot
Einige Änderungen unter den Top-Positionen
Die wertvollsten Fußballvereine der Welt 2019
Welcher Club ist am wertvollsten?
Promis
Diese Sternchen haben ihren eigenen Aktien-Index
Die erfolgreichsten Kinofilme der letzten 25 Jahre
Welche Titel knackten die Milliardenmarke an den Kinokassen?
Apps & Social Media: Die wertvollsten Marken der Welt
Welche Marke macht das Rennen?
mehr Top Rankings

Umfrage

Die Marktturbulenzen nehmen zu. Investieren Sie nun vermehrt in "sichere Häfen"?

Online Brokerage über finanzen.net

finanzen.net Brokerage
Handeln Sie für nur 5 Euro Orderprovision* pro Trade aus der Informationswelt von finanzen.net!

ETF-Sparplan

Oskar ist der einfache und intelligente ETF-Sparplan. Er übernimmt die ETF-Auswahl, ist steuersmart, transparent und kostengünstig.
Zur klassischen Ansicht wechseln
Kontakt - Impressum - Werben - Pressemehr anzeigen
Top News
Beliebte Suchen
DAX 30
Öl
Euro US-Dollar
Bitcoin
Goldpreis
Meistgesucht
MTU Aero Engines AG Em 2017A2G83P
Braas Monier Building Group S.A.BMSA01
XING (New Work)XNG888
Wirecard AG747206
EVOTEC SE566480
Deutsche Bank AG514000
Daimler AG710000
BayerBAY001
CommerzbankCBK100
SteinhoffA14XB9
NEL ASAA0B733
Microsoft Corp.870747
Amazon906866
Apple Inc.865985
BASFBASF11