26.03.2020 21:32

Innoplexus Announces Major Findings in Potential Combination Therapies for COVID-19


ESCHBORN, Germany, March 26, 2020 /PRNewswire/ -- Today, Innoplexus AG announced some first results in its artificial intelligence enabled search for a COVID-19 antiviral treatment. 

Innoplexus began by scanning data on previously approved drugs for off-label potential in treating COVID-19, using its proprietary artificial intelligence (AI) and big data platform to generate actionable insights from hundreds of terabytes of structured and unstructured public data, drawing from sources ranging from private research databases to social media.

Innoplexus processed hundreds of studies covering thousands of patients. Its AI-platform was used to analyze data coming from expression data, molecular pathways, drug binding affinities, and clinical trials published.

One of the most prominently upcoming drugs identified was Hydroxychloroquine, for which more than 200 reports were found. Hydroxychloroquine is a derivative of Chloroquine that has both antimalarial and anti-inflammatory activities. While some smaller studies with Hydroxychloroquine alone showed mixed results in fighting COVID-19 , Innoplexus' proprietary trial prediction engine suggests overall more limited response rates (response being defined as a shorter and less severe disease trajectory than would be seen in the absence of the drug) for ongoing and upcoming clinical trials for Hydroxychloroquine alone.

However, Hydroxychloroquine is a potential and immediately available treatment cost-effective option, although it could have major side effects for specific patient groups. The long-approved drug has been widely used as a prophylaxis for Malaria and as treatment for autoimmune diseases like rheumatoid arthritis and lupus. It is on the World Health Organization's list of essential medicines and has been prescribed five million times in the US in 2017 alone. Given that Hydroxychloroquine is out of patent and easy to produce, it is among the most promising stand-alone treatment options especially in emerging markets, where cost of treatment is expected to be a significant factor.

In an effort to improve the efficacy of treatments, Innoplexus used its AI platform to analyze drug pathways and interactions in their vast self-learning Knowledge Graphs – built over the entire universe of available biological data – to identify targets for human and virus proteins. Additionally, Innoplexus' AI evaluated the clinical potential of medications approved for other diseases to identify promising drug combinations that work synergistically to interrupt disease mechanisms.

These findings suggest that a combination of Hydroxychloroquine – or Chloroquine – with several previously approved drugs might yield better results than any drug administered alone. This hypothesis needs to be further evaluated in in-vitro and in -vivo research.

According to the AI-based analysis, a combination of Chloroquine and Tocilizumab, a drug approved to treat severe rheumatoid arthritis respectively. Tocilizumab is thought to interrupt the process of 'cytokine release syndrome' (CRS), a form of serious inflammatory response that can occur as a complication of COVID-19.

This first algorithm-based AI analysis of the data ocean also suggested that Chloroquine combined with Remdesivir, an antiviral drug developed by Gilead to treat Ebola, might also be effective. However, Remdesivir has not been approved yet for any indication and some first study results of Remdesivir alone showed limited efficacy. Our analysis suggests higher efficacy for a combination.

Finally, Hydroxychloroquine combined with Clarithromycin or Plerixafor, a semisynthetic macrolide antibiotic derived from erythromycin and an antiretroviral for HIV respectively, could be an option to be evaluated further. Plerixafor appears to act as an immunostimulant, while Clarithromycin seems to be able to block internalization of the virus into host cells during the early phase of infection. Despite safety concerns regarding Plerixafor it might have a positive effect in certain clinical settings.

Innoplexus is in the process of validating all of these combinations in vitro and in vivo studies.

"Our analysis has shown a good basis for allowing these combinations of previously approved drugs in off-label-use with further evaluation," said Dr. Gunjan Bhardwaj, Founder and CEO of Innoplexus. "As such, we recommend that governments and regulators take bold action and remove hurdles in order to substantially lower the incidence of critical and lethal cases of COVID-19. Confirmatory clinical studies should be done in parallel."

To further facilitate and expedite research, Innoplexus is offering its AI-based Clinical Trial Designer and Launch support solutions free of charge to any biotech or pharma company working on solutions to COVID-19.

Finally, Innoplexus has also generated potential candidates for novel molecules using its deep generative models powered by NVIDIA's DGX-1 supercomputers.

"This is crucial in order to be prepared for future viral strains," added Dr. Bhardwaj.

The two novel molecules target a specific virus protein and stop the growth of the virus. Initial results from in silico ADMET predictions and docking simulations showed improved efficacy compared to existing drugs. Additional tests are in progress.

Innoplexus AG

Innoplexus is a leading global AI-based platform for drug discovery and development with over 250 employees and 120+ patent filings including 14 grants in artificial intelligence, machine learning, and blockchain technologies. Innoplexus' solutions can generate real-time insights from hundreds of terabytes of structured and unstructured private and public data, thereby facilitating continuous, informed decision-making for its customer base at an unprecedented speed. Founded in 2015, Innoplexus AG is headquartered in Eschborn, Germany, with offices in Pune, India, as well as Hoboken, and San Francisco, United States.


Cision View original content:

SOURCE Innoplexus

Börse Stuttgart Anlegerclub

Die richtige Strategie für die Börsenkrise

Stecken Sie nicht den Sand in den Kopf, sondern kaufen Sie die richtigen Aktien. Erfahren Sie im aktuellen Anlegermagazin mehr über attraktive Qualitätsaktien und zyklische Aktien
Kostenfrei registrieren und lesen!

Heute im Fokus

DAX legt zu -- Asiens Börsen mehrheitlich fest -- SAP kappt Prognose für 2020 -- Gerresheimer bestätigt Jahresausblick -- UBS teilt Dividende auf -- Starbucks, Airbus im Fokus

Facebook führt Plattform für Hilfsangebote auch in Deutschland ein. Vergleichsportal: Weitere Geldhäuser bürden Sparern Negativzinsen auf. Diageo streicht Prognose. E.ON-Hauptversammlung soll virtuell stattfinden. Credit Suisse teilt Dividende in zwei Tranchen auf. Air France-KLM erwartet weitgehenden Geschäftsausfall bis Ende Mai.

Die 5 beliebtesten Top-Rankings

Die Länder mit den größten Goldreserven
Wer lagert das meiste Gold?
Welche Marken sind vorne mit dabei?
BrandZ-Ranking: Das sind die wertvollsten deutschen Marken
Das sind die besten Renten-Länder
In welchen Ländern lohnt es sich, zur Ruhe zu setzen?
Rohstoffe: Die Gewinner und Verlierer in Q1 2020
Welcher Rohstoff macht das Rennen?
MDAX: Die Gewinner und Verlierer in Q1 2020
Welche Aktie macht das Rennen?
mehr Top Rankings


Corona-Crash an den Börsen: Wird der DAX im April noch weiter fallen?

Online Brokerage über Brokerage
Handeln Sie für nur 5 Euro Orderprovision* pro Trade aus der Informationswelt von!


Oskar ist der einfache und intelligente ETF-Sparplan. Er übernimmt die ETF-Auswahl, ist steuersmart, transparent und kostengünstig.
Zur klassischen Ansicht wechseln
Kontakt - Impressum - Werben - Pressemehr anzeigen
Top News
Beliebte Suchen
DAX 30
Euro US-Dollar
Microsoft Corp.870747
Deutsche Bank AG514000
Wirecard AG747206
Scout24 AGA12DM8
Lufthansa AG823212
Daimler AG710000
Shell (Royal Dutch Shell) (A)A0D94M
Airbus SE (ex EADS)938914
Apple Inc.865985
Infineon AG623100