12.05.2022 16:28

Novartis data at ASCO and EHA showcase latest oncology research and innovation, including in breast and prostate cancer

Folgen
Werbung
  • Latest in HR+/HER2- metastatic breast cancer, including data on CDK recycling with Kisqali® plus endocrine therapy, further MONALEESA-2 quality of life and overall survival analyses, and a new biomarker analysis of Piqray® plus fulvestrant

  • Data for Tafinlar® + Mekinist® in pediatric patients with BRAF V600 low-grade glioma to be featured in ASCO official press briefing

  • First release of 96-week data on Scemblix® in Ph+ CML in chronic phase patients previously treated with =2 prior tyrosine kinase inhibitors

  • Updated next-generation CAR-T T-Charge™ data, and five-year results from ELIANA trial in pediatric and young adult ALL treated with Kymriah®, the first ever CAR-T cell therapy approved

  • Data from nearly 130 abstracts from Novartis-sponsored and investigator-initiated trials demonstrates Novartis commitment to push the boundaries of science and harness the power of innovation in established and investigational therapies and novel combinations

Basel, May 12, 2022 — Novartis highlights data from across its oncology portfolio at the upcoming 2022 American Society of Clinical Oncology (ASCO) Annual Meeting and the European Hematology Association (EHA) 2022 Hybrid Congress. With nearly 130 abstracts from Novartis-sponsored and investigator-initiated trials accepted, the data showcase research across over 20 compounds in key disease areas, including breast, lung and prostate cancers, leukemia, lymphoma, multiple myeloma and other blood disorders.

"We continue to push the boundaries of science with advanced therapies and novel combinations to help address the individual needs of patients,” said Marie-France Tschudin, President, Innovative Medicines International and Chief Commercial Officer, Novartis. "We are particularly excited about the latest data on CDK recycling with Kisqali, and first results for Tafinlar + Mekinist in a rare pediatric brain cancer.”

Key highlights of data accepted by ASCO:

Medicine Abstract Title Abstract Number/ Presentation Details
Kisqali® (ribociclib)*

 
A randomized phase II trial of fulvestrant or exemestane with or without ribociclib after progression on anti-estrogen therapy plus cyclin-dependent kinase 4/6 inhibition (CDK 4/6i) in patients (pts) with unresectable or hormone receptor positive (HR+), HER2 negative metastatic breast cancer (MBC): MAINTAIN trial Abstract # LBA1004
Oral Presentation:
Saturday, June 4, 1:15 PM – 4:15 PM CDT

 

 
Kisqali® (ribociclib)* Impact of ribociclib (RIB) dose modifications (mod) on overall survival (OS) in patients (pts) with HR+/HER2- advanced breast cancer (ABC) in MONALEESA (ML)-2 Abstract #1017
Poster Discussion:
Monday, June 6, 8:00 AM – 11:00 AM CDT
Kisqali® (ribociclib)*

 
Quality of life (QOL) with ribociclib (RIB) plus aromatase inhibitor (AI) vs abemaciclib (ABE) plus AI as first-line (1L) treatment (tx) of hormone receptor–positive/human epidermal growth factor receptor–negative (HR+/HER2-) advanced breast cancer (ABC), assessed via matching-adjusted indirect comparison (MAIC) Abstract #1015
Poster Discussion:
Monday, June 6, 8:00 AM – 11:00 AM CDT

 
Piqray® (alpelisib) Alpelisib (ALP) + Fulvestrant (FUL) in Patients (pts) With Hormone Receptor-Positive (HR+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-), Advanced Breast Cancer (ABC): Biomarker (BM) Analyses by Next-Generation Sequencing (NGS) From the SOLAR-1 Study Abstract #1006
Oral Presentation:
Saturday, June 4, 1:15 PM – 4:15 PM CDT
Piqray® (alpelisib)

 
Alpelisib (ALP) + endocrine therapy (ET) in patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–), PIK3CA-mutated (mut) advanced breast cancer (ABC): Baseline biomarker analysis and progression-free survival (PFS) by duration of prior cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) therapy in the BYLieve study Abstract #1018
Poster Discussion:
Monday, June 6, 8:00 AM – 11:00 AM CDT

 

 
Scemblix® (asciminib) Efficacy and safety results from ASCEMBL, a phase 3 study of asciminib vs bosutinib (BOS) in patients (pts) with chronic myeloid leukemia in chronic phase (CML-CP) after =2 prior tyrosine kinase inhibitors (TKIs): wk 96 update Abstract #7004
Oral Presentation:
Tuesday, June 7, 9:45 AM – 12:45 PM CDT
Tafinlar® (dabrafenib) / Mekinist® (trametinib) Primary analysis of a phase II trial of dabrafenib + trametinib (dab + tram) in BRAF V600–mutant pediatric low-grade glioma (pLGG) Abstract #2002
Oral Presentation:
Monday, June 6, 11:30 AM – 2:30 PM CDT
Pluvicto™ (lutetium Lu 177 vipivotide tetraxetan) (formerly referred to as 177Lu-PSMA-617) 177Lu-PSMA-617 in PSMA-positive metastatic castration-resistant prostate cancer: prior and concomitant treatment subgroup analyses of the VISION trial

 
Abstract #5001
Oral Presentation:
Sunday, June 5, 8:00 AM – 11:00 AM CDT

 
Pluvicto™ (lutetium Lu 177 vipivotide tetraxetan) Tolerability of 177Lu-PSMA-617 by treatment exposure in patients with metastatic castration-resistant prostate cancer (mCRPC): a VISION study subgroup analysis Abstract #5047
Poster available:
Monday, June 6, 1:15 PM – 4:15 PM CDT
Locametz® (kit for the preparation of gallium Ga 68 gozetotide injection)** 68Ga-PSMA-11 PET baseline imaging as a prognostic tool for clinical outcomes to 177Lu-PSMA-617 in patients with mCRPC: a VISION sub-study Abstract #5002
Oral Presentation:
Sunday, June 5, 8:00 AM – 11:00 AM CDT
Lutathera® (lutetium Lu 177 dotatate)*** Effectiveness and safety of re-treatment with lutetium Lu 177 dotatate in patients with progressive neuroendocrine tumors in the United States: a retrospective real-world study Abstract #e16215

 

Key highlights of data accepted by EHA:

Medicine Abstract Title Abstract Number/ Presentation Details
Scemblix® (asciminib) Efficacy and safety results from ASCEMBL, a phase 3 study of asciminib vs bosutinib in patients with chronic myeloid leukemia in chronic phase after =2 prior tyrosine kinase inhibitors: week 96 update Abstract #S155
Oral Presentation:
Sunday, June 12, 11:30 AM – 12:45 PM CEST
Scemblix® (asciminib) Asciminib provides durable molecular responses in patients (Pts) with chronic myeloid leukemia in chronic phase (CML-CP) with the T315I mutation: Updated efficacy and safety data from a Phase 1 trial Abstract #P704
Poster Available:
Friday, June 10, 4:30 PM – 5:45 PM CEST
Kymriah® 
(tisagenlecleucel)
Tisagenlecleucel in pediatric and young adult patients (Pts) with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL): Final analyses from the ELIANA study Abstract #S112
Oral Presentation:
Sunday, June 12, 11:30 AM – 12:45 PM CEST

 
YTB323 Phase I study of YTB323, a chimeric antigen receptor (CAR)-T cell therapy manufactured using T-Charge™, in patients with relapsed/refractory diffuse large B-cell lymphoma Abstract #S212
Oral Presentation:
Saturday, June 11, 11:30 AM – 12:45 PM CEST
PHE885 Phase I study data update of PHE885, a fully human BCMA-directed CAR-T cell therapy manufactured using the T-Charge™ platform for patients with relapsed/refractory (R/R) multiple myeloma (MM) Abstract #P1446
Poster Available:
Friday, June 10, 4:30 PM – 5:45 PM CEST
Sabatolimab First results of a Phase II study (STIMULUS-AML1) investigating sabatolimab + azacitidine + venetoclax in patients with newly diagnosed acute myeloid leukemia Abstract #P582
Poster available:
Friday, June 10, 4:30 PM – 5:45 PM CEST

 
Promacta/Revolade®
(eltrombopag)
Sustained response off treatment in eltrombopag-treated patients with ITP who are refractory or relapsed after first-line steroids: primary analysis of the phase II TAPER trial Abstract #S292
Oral Presentation
Saturday, June 11, 11:30 AM – 12:45 PM CEST  

Product Information
For full prescribing information, including approved indications and important safety information about marketed products, please visit https://www.novartisoncology.com/news/product-portfolio.

Disclaimer
This press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements can generally be identified by words such as "potential,” "can,” "will,” "plan,” "may,” "could,” "would,” "expect,” "anticipate,” "seek,” "look forward,” "believe,” "committed,” "investigational,” "pipeline,” "launch,” or similar terms, or by express or implied discussions regarding potential marketing approvals, new indications or labeling for the investigational or approved products described in this press release, or regarding potential future revenues from such products. You should not place undue reliance on these statements. Such forward-looking statements are based on our current beliefs and expectations regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that the investigational or approved products described in this press release will be submitted or approved for sale or for any additional indications or labeling in any market, or at any particular time. Nor can there be any guarantee that such products will be commercially successful in the future. In particular, our expectations regarding such products could be affected by, among other things, the uncertainties inherent in research and development, including clinical trial results and additional analysis of existing clinical data; regulatory actions or delays or government regulation generally; global trends toward health care cost containment, including government, payor and general public pricing and reimbursement pressures and requirements for increased pricing transparency; our ability to obtain or maintain proprietary intellectual property protection; the particular prescribing preferences of physicians and patients; general political, economic and business conditions, including the effects of and efforts to mitigate pandemic diseases such as COVID-19; safety, quality, data integrity or manufacturing issues; potential or actual data security and data privacy breaches, or disruptions of our information technology systems, and other risks and factors referred to in Novartis AG’s current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.

About Novartis
Novartis is reimagining medicine to improve and extend people’s lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. In our quest to find new medicines, we consistently rank among the world’s top companies investing in research and development. Novartis products reach nearly 800 million people globally and we are finding innovative ways to expand access to our latest treatments. About 108,000 people of more than 140 nationalities work at Novartis around the world. Find out more at https://www.novartis.com.

Novartis is on Twitter. Sign up to follow @Novartis at https://twitter.com/novartisnews
For Novartis multimedia content, please visit https://www.novartis.com/news/media-library
For questions about the site or required registration, please contact media.relations@novartis.com

# # #

* Kisqali was developed by the Novartis Institutes for BioMedical Research (NIBR) under a research collaboration with Astex Pharmaceuticals.
† Investigator-initiated trial
** Locametz is a registered trademark of Advanced Accelerator Applications, a Novartis company.
*** Lutathera is a registered trademark of Advanced Accelerator Applications, a Novartis company.

Novartis Media Relations
E-mail: media.relations@novartis.com

Anja von Treskow
Novartis External Communications
+41 79 392 8697 (mobile)
anja.von_treskow@novartis.com

 

Amy Wolf
Novartis External Communications
+41 79 576 07 23 (mobile)
amy.wolf@novartis.com
Michael Billings
Novartis Oncology Communications
+1 862 778 8656 (direct)
+1 201 400 1854 (mobile)
michael.billings@novartis.com

 

Julie Masow
Novartis US External Communications
+1 862 579 8456
Julie.masow@novartis.com

 

Novartis Investor Relations
Central investor relations line: +41 61 324 7944
E-mail: investor.relations@novartis.com

Central   North America  
Samir Shah +41 61 324 7944 Sloan Simpson +1 862 345 4440
Nicole Zinsli-Somm +41 61 324 3809 Alina Levchuk +1 862 778 3372
Isabella Zinck +41 61 324 7188 Parag Mahanti +1 973-876-4912

Ausgewählte Hebelprodukte auf Novartis AG
Mit Knock-outs können spekulative Anleger überproportional an Kursbewegungen partizipieren. Wählen Sie einfach den gewünschten Hebel und wir zeigen Ihnen passende Open-End Produkte auf Novartis AG
Long
Short
Hebel wählen:
5x
10x
Name
Hebel
KO
Emittent

Nachrichten zu Novartis AG

  • Relevant
  • Alle
  • vom Unternehmen
  • Peer Group
  • ?

Um Ihnen die Übersicht über die große Anzahl an Nachrichten, die jeden Tag für ein Unternehmen erscheinen, etwas zu erleichtern, haben wir den Nachrichtenfeed in folgende Kategorien aufgeteilt:

Relevant: Nachrichten von ausgesuchten Quellen, die sich im Speziellen mit diesem Unternehmen befassen

Alle: Alle Nachrichten, die dieses Unternehmen betreffen. Z.B. auch Marktberichte die außerdem auch andere Unternehmen betreffen

vom Unternehmen: Nachrichten und Adhoc-Meldungen, die vom Unternehmen selbst veröffentlicht werden

Peer Group: Nachrichten von Unternehmen, die zur Peer Group gehören

Analysen zu Novartis AG

  • Alle
  • Buy
  • Hold
  • Sell
  • ?
22.06.2022Novartis NeutralUBS AG
22.06.2022Novartis UnderweightJP Morgan Chase & Co.
22.06.2022Novartis SellDeutsche Bank AG
27.05.2022Novartis BuyJoh. Berenberg, Gossler & Co. KG (Berenberg Bank)
05.05.2022Novartis BuyJoh. Berenberg, Gossler & Co. KG (Berenberg Bank)
27.05.2022Novartis BuyJoh. Berenberg, Gossler & Co. KG (Berenberg Bank)
05.05.2022Novartis BuyJoh. Berenberg, Gossler & Co. KG (Berenberg Bank)
28.04.2022Novartis Conviction Buy ListGoldman Sachs Group Inc.
26.04.2022Novartis BuyJefferies & Company Inc.
19.04.2022Novartis BuyJefferies & Company Inc.
22.06.2022Novartis NeutralUBS AG
27.04.2022Novartis NeutralCredit Suisse Group
27.04.2022Novartis NeutralUBS AG
26.04.2022Novartis NeutralUBS AG
08.04.2022Novartis NeutralUBS AG
22.06.2022Novartis UnderweightJP Morgan Chase & Co.
22.06.2022Novartis SellDeutsche Bank AG
27.04.2022Novartis UnderweightJP Morgan Chase & Co.
27.04.2022Novartis SellDeutsche Bank AG
26.04.2022Novartis UnderweightJP Morgan Chase & Co.

Um die Übersicht zu verbessern, haben Sie die Möglichkeit, die Analysen für Novartis AG nach folgenden Kriterien zu filtern.

Alle: Alle Empfehlungen

Buy: Kaufempfehlungen wie z.B. "kaufen" oder "buy"

Hold: Halten-Empfehlungen wie z.B. "halten" oder "neutral"

Sell: Verkaufsempfehlungn wie z.B. "verkaufen" oder "reduce"
mehr Analysen

Jetzt noch kostenlos anmelden!

Inflation, Leitzinserhöhung und Bärenmärkte - aber wie sieht es eigentlich am Immobilienmarkt aus? Wenn auch Sie sich den Traum einer eigenen Immobilie erfüllen möchten, erfahren Sie im Online-Seminar am Montag um 18 Uhr wie Sie Schritt für Schritt das passende Objekt finden und welche Finanzierungsmöglichkeiten es gibt!

Werbung
Werbung
Werbung
Neue Funktionen als Erstes nutzen
Sie nutzen finanzen.net regelmäßig? Dann nutzen Sie jetzt neue Funktionen als Erstes!
Hier informieren!
Werbung
Börse Stuttgart Anlegerclub
Werbung

Heute im Fokus

Ukraine-Krieg im Ticker: DAX schließt Freitagshandel über 13.100 Punkten -- US-Börsen legen markant zu -- Zalando kassiert Jahresprognose -- GAZPROM, TUI, Porsche-IPO, Amazon, Deutsche Bank im Fokus

IMMOFINANZ will Objekte in Milliardenwert verkaufen. Streik des Kabinen-Personals führt zu Flug-Ausfällen bei Ryanair. Henkel macht laut CEO Knobel Fortschritte beim Rückzug aus Russland. RWE plant Wasserstoff-Produktionsanlage in Rostock. Stellantis steigt bei Lithium-Unternehmen Vulcan Energy ein. Stifel startet Vonovia mit "Hold". Zurich trennt sich von deutschen Lebensversicherungs-Altbeständen.

Umfrage

Sollte das 9-Euro-Ticket über den August hinaus verlängert werden?

finanzen.net zero
finanzen.net zero

Oskar

ETF-Sparplan

Oskar ist der einfache und intelligente ETF-Sparplan. Er übernimmt die ETF-Auswahl, ist steuersmart, transparent und kostengünstig.
Zur klassischen Ansicht wechseln