01.09.2019 14:29

Press Release: Novartis PARAGON-HF trial suggests -2-

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or regarding potential future revenues from Entresto. You should not

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[1] Solomon S, McMurray J, et al. Angiotensin-Neprilysin in Heart

Failure with Preserved Ejection Fraction. N Engl J Med. 2019; doi:


[2] Ponikowski P, Voors A, et al. 2016 ESC Guidelines for the diagnosis

and treatment of acute and chronic heart failure. Eur Heart J.

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[3] Treatment for Heart Failure: Endpoints for Drug Development

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Food and Drug Administration, Center for Drug Evaluation and Research

(CDER) and Center for Biologics Evaluation and Research (CBER). June

2019. Available at: Accessed

July 17, 2019.

[4] McMurray J, Packer M, Desai A, et al. Angiotensin-neprilysin

inhibition versus enalapril in heart failure. N Engl J Med.

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[5] Seferovic P, Ponikowski P, Anker S, et al. Clinical practice update

on heart failure 2019: pharmacotherapy, procedures, devices and patient

management. An expert consensus meeting report of The Heart Failure

Association of the European Society of Cardiology. Eur J Heart Fail.

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[6] Velazquez E, Morrow D, DeVore, A, et al., Angiotensin-Neprilysin

Inhibition in Acute Decompensated Heart Failure. N Engl J Med. 2018.

doi: 10.1056/NEJMoa1812851.

[7] Chandra A, Lewis E, Claggertt B, et al. The Effects of

Sacubitril/Valsartan on Physical and Social Activity Limitations in

Heart Failure Patients: The PARADIGM-HF Trial. JAMA Cardiol.

2018;3(6):498-505. doi: 10.1001/jamacardio.2018.0398.

[8] EMA. Entresto (sacubitril/valsartan). Summary of product

characteristics. Available at:

Accessed July 2019.

[9] Yancy C, Jessup M, et al. 2017 ACC/AHA/HFSA Focused Update of the

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the American College of Cardiology/American Heart Association Task Force

on Clinical Practice Guidelines and the Heart Failure Society of

America. Circulation. 2017;136:e137-161. doi:


[10] Solomon S, Rizkala A, et al. Angiotensin Receptor Neprilysin

Inhibition in Heart Failure with Preserved Ejection Fraction: Rationale

and Design of the PARAGON-HF Trial. JACC Heart Fail. 2017;5(7):471-482.

doi: 10.1016/j.jchf.2017.04.013.

[11] Solomon S, Zile M, et al. The angiotensin receptor neprilysin

inhibitor LCZ696 in heart failure with preserved ejection fraction: a

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2012;380(9851):1387-1395. doi: 10.1016/S0140-6736(12)61227-6.

[12] Ndumele C, Matsushita K, et al. NT-proBNP and Heart Failure Risk

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[13] What is Heart Failure? American Heart Association. Website.

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[14] Savarese G, Lund L. Global Public Health Burden of Heart Failure.

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[15] Borlaug B, Redfield M. Distolic and systolic heart failure are

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[16] Ejection Fraction Heart Failure Measurement. American Heart

Association. Website.

Published March 24, 2015. Accessed July 17, 2019.

[17] Dunlay S, Roger V, et al. Epidemiology of heart failure with

preserved ejection fraction. Nature Reviews Cardiology.

2017;14:591--602. doi: 10.1038/nrcardio.2017.65.

[18] Oktay A, Rich J, et al. The Emerging Epidemic of Heart Failure

with Preserved Ejection Fraction. Curr Heart Fail Rep.

2013;10(4):401-410. doi:10.1007/s11897-013-0155-7.

[19] Yancy C, Jessup M, et al. 2013 ACCF/AHA Guideline for the

Management of Heart Failure. J Am Coll Cardiol. 2013;62(16):e147-e239.

doi: 10.1016/j.jacc.2013.05.019.

[20] Owan T, Hodge D, et al. Trends in prevalence and outcome of heart

failure with preserved ejection fraction. N Engl J Med.

2006;355:251-259. doi: 10.1056/NEJMoa052256.

[21] Yancy C, Jessup M, et al. 2017 ACC/AHA/HFSA Focused Update of the

2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of

the American College of Cardiology/American Heart Association Task Force

on Clinical Practice Guidelines and the Heart Failure Society of

America. Circulation. 2017;136:e137-161. doi:


[22] Langenickel T, Dole W. Angiotensin receptor-neprilysin inhibition

with LCZ696: a novel approach for the treatment of heart failure. Drug

Discov Today. 2012;9(4):e131-139. doi: 10.1016/j.ddstr.2013.11.002.

[23] ENTRESTO [prescribing information]. East Hanover, NJ: Novartis

Pharmaceuticals Corp; November 2018.

[24] Desai A, Claggett B, et al. Influence of Sacubitril/Valsartan

(LCZ696) on 30-Day Readmission After Heart Failure Hospitalization.

JACC. 2016;68(3):241-248. doi: 10.1016/j.jacc.2016.04.047.

# # #

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(END) Dow Jones Newswires

September 01, 2019 08:30 ET (12:30 GMT)

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