SenesTech's Evolve™ Rodent Birth Control Proven in Urban Rodent Hotspots from Hong Kong to San Francisco

Pallet and Container Orders Expected for Resupply and Expansion

SURPRISE, Ariz., June 26, 2025 /PRNewswire/ -- SenesTech, Inc. (NASDAQ: SNES, "SenesTech" or the "Company"), a leader in fertility control for managing animal pest populations, today announced compelling results from two major urban deployments — one in Hong Kong and one in San Francisco — showing how pairing Evolve™ Rat Birth Control with traditional poison bait stations delivers faster, more sustainable rodent control where it's needed most.

Global Cities Face Persistent Rodent Pressure
Urban centers worldwide face constant rodent challenges due to dense infrastructure, hard-to-access breeding sites, and abundant food sources. Even the most aggressive traditional rodenticide programs often fall short over time, as rodents adapt to poisons and continue to reproduce unchecked.

A Breakthrough: Combining Fertility Control with Traditional Rodenticides
In both Hong Kong and San Francisco, pest management teams implemented a novel integrated strategy: deploying Evolve's palatable soft bait alongside conventional rodenticide blocks within standard bait stations across infested buildings and surrounding areas.

This hybrid approach tackles two critical issues simultaneously:

• Immediate population knockdown via targeted poison baiting
• Long-term population suppression by disrupting rodent reproduction cycles with fertility control

In Hong Kong, this method was applied in a high-density mixed-use building with persistent rodent activity. Within three months, sightings fell dramatically, bait consumption declined as the population shrank, and no new litters were detected — breaking the cycle of reinfestation that had frustrated property managers for years.

Further details on this study can be read here.

In San Francisco, an urban deployment in a heavily trafficked neighborhood known for recurring infestations achieved similar success: a clear reduction in visible rodent activity, less poison used overall, and a measurable drop in new rodent births.

A New Industry Standard for Sustainable Urban IPM
"These successes prove that fertility control isn't just an idea — it's a practical tool that helps pest professionals get ahead of chronic infestations faster and with less rodenticide. Deploying Evolve alongside bait blocks strengthens any IPM program. Cities worldwide can benefit from this smarter, more sustainable approach," said Joel Fruendt, CEO of SenesTech. "These kinds of validating results are also what trigger rapid expansion – we are currently preparing for a container-sized order from Hong Kong, for example."

Delivering Value to Investors and Operators
Fertility control solutions like Evolve align with changing environmental regulations and public demand for humane, low-toxicity pest management. For pest control professionals and property owners, this means improved outcomes, new service offerings, and better ROI from each deployment. For investors, it signals a rapidly growing global market for next-generation rodent control solutions that complement and enhance traditional tools.

About SenesTech
We are committed to improving the health of the world by humanely managing animal pest populations through our expertise in fertility control. We invented ContraPest^®, the only U.S. EPA-registered contraceptive for male and female rats, as well as Evolve™ Rat and Evolve™ Mouse, EPA-designated minimum risk contraceptives for rodents, reflecting our mission to provide products that are proactive, safe and sustainable. ContraPest and Evolve fit seamlessly into all integrated pest management programs, significantly improving the overall goal of effective pest management. We strive for clean cities, efficient businesses and happy households – with a product designed to be humane, effective and sustainable.

For more information visit https://senestech.com/.

Safe Harbor Statement
This press release contains "forward-looking statements" within the meaning of federal securities laws, and we intend that such forward-looking statements be subject to the safe harbor created thereby. Such forward-looking statements include, among others, our belief that pairing Evolve with traditional poison bait stations delivers faster, more sustainable rodent control where it's needed most; our belief that fertility control is a practical tool that helps pest professionals get ahead of chronic infestations faster and with less rodenticide; our belief that deploying Evolve alongside bait blocks strengthens any IPM program; our belief that cities worldwide can benefit from this smarter, more sustainable approach; our belief that fertility control solutions like Evolve align with changing environmental regulations and public demand for humane, low-toxicity pest management, meaning improved outcomes, new service offerings, and better ROI from each deployment for pest control professionals and property owners, and signaling to investors a rapidly growing global market for next-generation rodent control solutions that complement and enhance traditional tools. Forward-looking statements may describe future expectations, plans, results or strategies and are often, but not always, made through the use of words such as "believe," "may," "future," "plan," "will," "should," "expect," "anticipate," "eventually," "project," "estimate," "continuing," "intend" and similar words or phrases. You are cautioned that such statements are subject to risks, uncertainties and other factors that could cause actual results to differ materially from those reflected by such forward-looking statements. Such factors include, among others, the successful commercialization of our products, market acceptance of our products, regulatory approval and regulation of our products and other factors and risks identified from time to time in our filings with the Securities and Exchange Commission, including our Annual Report on Form 10-K for the fiscal year ended December 31, 2024. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on management's assumptions and estimates as of such date. Except as required by law, we do not undertake any obligation to publicly update any forward-looking statements, whether as a result of the receipt of new information, the occurrence of future events or otherwise.

Contact Information:
Investors:
Robert Blum, Lytham Partners, LLC
(602) 889-9700
senestech@lythampartners.com

Marketing:
Rochelle Paulet, Director of Marketing, SenesTech, Inc.
(928) 779-4143 x814

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SOURCE SenesTech, Inc.