Designs for Health Introduces Revolutionary Gut Health Supplement Anaerostipes Probiotic

Next-generation probiotic featuring ClostraBio's Anaerostipes caccae CLB101™ delivers direct butyrate production, microbiome diversity support, and gut barrier strength 

PALM COAST, Fla., Sept. 24, 2025 /PRNewswire/ -- Designs for Health^®, the practitioner-recommended and preferred brand for high-quality, research-backed supplements, today announced the launch of Anaerostipes Probiotic, an industry-first probiotic featuring Anaerostipes caccae CLB101™, a powerful new probiotic strain that helps strengthen the gut lining, support healthy digestion, and promote overall gut balance.*

This innovative formulation represents a major advancement in microbiome science. Unlike conventional probiotics, Anaerostipes is specifically designed to target the root causes of gut dysfunction through the introduction of Anaerostipes caccae CLB101™, a next-generation keystone strain known for its ability to directly produce butyrate, a vital byproduct from microbial gut fermentation (aka short-chain fatty acids). Butyrate fuels the cell lining between the gut and bloodstream called colonocytes, supports gut barrier integrity, and helps to improve immune function.* Anaerostipes thrives in the low-oxygen environment of the colon and can be negatively impacted by certain bowel conditions and other metabolic disorders, highlighting its significance in maintaining a healthy microbiome. Anaerostipes caccae CLB101™ is the key strain to convert unwanted lactate into butyrate, addressing the challenge that undigested carbohydrates are fermented by bacteria into D-lactate, which the human body poorly metabolizes. Anaerostipes caccae CLB101™ also plays a central role in shaping a healthy microbial ecosystem by crossfeeding other beneficial gut microbes and promoting microbial diversity, essential factors for long-term gastrointestinal resilience.

Consumer interest in gut health has never been stronger. Approximately one-third (32%) of consumers actively try to consume probiotics; of those, 60% aim to consume them at least once a day, highlighting a growing demand for more effective, science-backed solutions like Anaerostipes Probiotic.

"Anaerostipes is not just another probiotic, it's a leap forward in gut health innovation," said Dr. David M. Brady, Chief Medical Officer at Designs for Health. "By reintroducing a keystone organism like Anaerostipes caccae CLB101™, we're able to influence the entire microbial environment in a way that supports barrier function, immune regulation, and metabolic signaling, the core pillars of long-term GI health."

The probiotic is delivered in a convenient, once-daily capsule designed for clinical reliability and ease of use. Its formulation supports four key pillars of digestive health including microbiome diversity, gut barrier function, regularity, and digestive comfort.* For patients, this means renewed confidence around mealtime, a shift from food fear to food freedom. Anaerostipes Probiotic offers a powerful clinical tool for functional and integrative health practitioners to support their patients with a range of GI conditions. Its science-forward design makes it ideal for protocols that aim to support the gut lining, promote healthy inflammatory responses, and support sustainable microbiome restoration.

"The launch of Anaerostipes reflects our unwavering commitment to advancing the science of nutrition and delivering real solutions that address the root causes of health challenges," said Amardeep Kahlon, Chief Executive Officer at Designs for Health. "As a brand built on clinical integrity and innovation, we strive to equip practitioners with cutting-edge tools that improve patient outcomes and redefine what's possible in functional medicine."

"With its focus on innovative, science-backed ingredients and leadership role in the functional medicine space, Designs for Health was the obvious partner to commercialize the first dietary supplement containing our next-generation Anaerostipes caccae CLB101™ ingredient", noted Ritu Shah, CEO of ClostraBio. "Designs for Health has the team and the experience required to educate both health-care practitioners and consumers on the important role for both CLB101™ and butyrate in gut health."

Anaerostipes Probiotic is now available for purchase on DesignsforHealth.com. To learn more about Designs for Health and its comprehensive portfolio of products, visit https://www.designsforhealth.com.

About ClostraBio, Inc.
ClostraBio, a University of Chicago spinout incubated at Portal Innovations, develops products for gut health using a science-driven approach. CLB101™ is a next-generation, targeted-action probiotic, and the Company's polymeric prodrug platform delivers small molecules to the lower gut.

About Designs for Health, Inc.
Family-owned Designs for Health, Inc. offers high-quality nutritional supplements and functional foods to health-care professionals and their patients. Guided by its founding philosophy of "Science-First™," the company holds an unwavering commitment to creating research-driven formulations with meaningful quantities of functional ingredients that maximize the potential for successful health outcomes. For over 36 years, Designs for Health has been many health-care professionals' trusted source for not only product innovation but also leadership in clinical education and practice development solutions. https://www.designsforhealth.com/our-story 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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SOURCE Designs for Health