Press Release: Novartis Fabhalta(R) shows -2-

12.06.25 07:59 Uhr

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actual data security and data privacy breaches, or disruptions of our information technology systems, and other risks and factors referred to in Novartis AG's current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this media update as of this date and does not undertake any obligation to update any forward-looking statements contained in this media update as a result of new information, future events or otherwise.

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Daily Oral LNP023 in Adult PNH Patients With Residual Anemia Despite

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Daily Oral Iptacopan (LNP023) in Adult PNH Patients Who Are Naive to

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21. Kavanagh D, Bomback A, Vivarelli M, et al. Efficacy and Safety of

Iptacopan in Patients with C3 Glomerulopathy: Results from the Phase 3

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(ASN) Kidney Week 2024; October 23-27, 2024; San Diego, CA.

23. Novartis. Press release. Novartis receives FDA approval for Fabhalta(R)

(iptacopan), offering superior hemoglobin improvement in the absence of

transfusions as the first oral monotherapy for adults with PNH. Available

from:

https://www.novartis.com/news/media-releases/novartis-receives-fda-approval-fabhalta-iptacopan-offering-superior-hemoglobin-improvement-absence-transfusions-first-oral-monotherapy-adults-pnh

Accessed May, 2025.

24. Novartis. Press release. Novartis receives FDA accelerated approval for

Fabhalta(R) (iptacopan), the first and only complement inhibitor for the

reduction of proteinuria in primary IgA nephropathy (IgAN). Available

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https://www.novartis.com/news/media-releases/novartis-receives-fda-accelerated-approval-fabhalta-iptacopan-first-and-only-complement-inhibitor-reduction-proteinuria-primary-iga-nephropathy-igan

Accessed May, 2025.

25. Novartis. Press release. Novartis receives third FDA approval for oral

Fabhalta(R) (iptacopan) -- the first and only treatment approved in C3

glomerulopathy (C3G). Available from:

https://www.novartis.com/news/media-releases/novartis-receives-third-fda-approval-oral-fabhalta-iptacopan-first-and-only-treatment-approved-c3-glomerulopathy-c3g

Accessed May, 2025.

26. Novartis. Press release. Novartis oral Fabhalta(R) (iptacopan) receives

positive CHMP opinion for the treatment of adults living with C3

glomerulopathy (C3G). Available from:

https://www.novartis.com/news/media-releases/novartis-oral-fabhalta-iptacopan-receives-positive-chmp-opinion-treatment-adults-living-c3-glomerulopathy-c3g

Accessed May, 2025.

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1lbl.pdf Accessed May, 2025.

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(LNP023) in Adult Patients With Atypical Hemolytic Uremic Syndrome Naive

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