Zoetis Gains CVMP Backing for Lenivia, Eyes EU Approval in Dog OA Pain

Zoetis ZTS announced that the European Medicines Agency’s Committee for Veterinary Medicinal Products (CVMP) has issued a positive opinion for its investigational monoclonal antibody (mAb) therapy, Lenivia (izenivetmab). The recommendation supports granting marketing authorization for the candidate, which has been developed to help relieve pain associated with osteoarthritis (OA) in dogs.Based on the CVMP’s recommendation, Zoetis expects the European regulatory body to communicate a final decision during the fourth quarter of 2025. Subject to a favorable outcome, the company anticipates making Lenivia commercially available in the EU in 2026.What an EU Nod for Lenivia Will Mean for ZTS?If it secures an EU approval, Zoetis’ Lenivia would represent a new antibody-based treatment designed to relieve OA pain in dogs for up to three months with a single injection. The therapy targets nerve growth factor (NGF), a key mediator of pain and inflammation, through its novel binding mechanism. Backed by more than a decade of research, Lenivia has demonstrated a favorable safety profile in a nine-month field study, where treated dogs showed improved mobility and reduced pain following a single dose.ZTS shares have lost 13.4% year to date against the industry’s 6.8% growth.Image Source: Zacks Investment ResearchFor Zoetis, the potential approval of Lenivia not only reinforces its leadership in the animal health sector but also expands its innovative portfolio in companion animal therapeutics. By offering veterinarians and pet owners a novel, convenient option for managing OA pain in dogs, the company stands to strengthen its market presence in the EU and beyond, thereby boosting its revenue stream.OA is a prevalent, chronic and progressive joint disorder marked by inflammation and cartilage degradation, leading to pain and reduced mobility. While there is no cure, effective management can significantly alleviate pain and enhance quality of life. It is estimated that OA-related pain affects nearly 40% of dogs across all ages and breeds, with chronic pain often impairing movement, sleep, behavior and social interactions.ZTS’ Lenivia Set to Complement Librela for OA Pain in DogsZoetis’ latest candidate, Lenivia, is poised to expand its OA pain management portfolio for dogs, joining Librela (bedinvetmab), also a mAb therapy that targets NGF, upon approval. While Librela offers monthly pain relief, Lenivia (if approved) would provide a long-acting alternative with dosing required only once every three months. This dual offering would allow veterinarians and dog owners to choose between monthly and quarterly treatment schedules, broadening ZTS’ reach in the canine OA market and reinforcing its leadership in veterinary pain management.We remind the investors that, last month, Zoetis received a positive opinion from the European Medicines Agency’s CVMP recommending approval of Portela (relfovetmab), its investigational mAb therapy for managing OA pain in cats. Like Lenivia, Portela is also designed to provide up to three months of pain relief with a single injection. A final EU decision is expected in late 2025, with potential launch in 2026. If approved, Portela would become the first long-acting anti-NGF therapy for feline OA pain and complement Zoetis’ existing monthly OA treatment, Solensia (frunevetmab).With Librela and Solensia already demonstrating clinical and real-world success, the addition of Lenivia and Portela could deepen Zoetis’ penetration into the growing canine/feline OA segment, while also improving treatment adherence due to its less frequent dosing schedule.Zoetis Inc. Price and Consensus Zoetis Inc. price-consensus-chart | Zoetis Inc. QuoteZTS’ Zacks Rank & Stocks to ConsiderZoetis currently carries a Zacks Rank #3 (Hold).Some better-ranked stocks in the biotech sector are ADC Therapeutics ADCT, Allogene Therapeutics ALLO and Chemomab Therapeutics CMMB, each carrying a Zacks Rank #2 (Buy) at present. You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.In the past 60 days, estimates for ADC Therapeutics’ 2025 loss per share have narrowed from $1.77 to $1.68. However, loss per share estimates for 2026 have widened from $1.62 to $1.97 during the same period. ADCT stock has surged 122.1% year to date.ADC Therapeutics’ earnings beat estimates in two of the trailing four quarters while missing the same on the other two occasions, the average negative surprise being 8.29%.In the past 60 days, estimates for Allogene Therapeutics’ 2025 loss per share have narrowed from $1.02 to 96 cents. Loss per share estimates for 2026 have narrowed from 98 cents to 86 cents during the same period. ALLO stock has lost 42.3% year to date.Allogene Therapeutics’ earnings beat estimates in three of the trailing four quarters, while meeting the same on the remaining occasion, with an average surprise of 14.03%.In the past 60 days, estimates for Chemomab Therapeutics’ 2025 loss per share have narrowed from $2.40 to 60 cents. Loss per share estimates for 2026 have narrowed from $2.80 to $1.00 during the same period. CMMB stock has plunged 54.7% year to date.Chemomab Therapeutics’ earnings beat estimates in three of the trailing four quarters, while meeting the same on the remaining occasion, with an average surprise of 26.25%.Radical New Technology Could Hand Investors Huge GainsQuantum Computing is the next technological revolution, and it could be even more advanced than AI.While some believed the technology was years away, it is already present and moving fast. Large hyperscalers, such as Microsoft, Google, Amazon, Oracle, and even Meta and Tesla, are scrambling to integrate quantum computing into their infrastructure.Senior Stock Strategist Kevin Cook reveals 7 carefully selected stocks poised to dominate the quantum computing landscape in his report, Beyond AI: The Quantum Leap in Computing Power.Kevin was among the early experts who recognized NVIDIA's enormous potential back in 2016. Now, he has keyed in on what could be "the next big thing" in quantum computing supremacy. Today, you have a rare chance to position your portfolio at the forefront of this opportunity.See Top Quantum Stocks Now >>Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report ADC Therapeutics SA (ADCT): Free Stock Analysis Report Zoetis Inc. (ZTS): Free Stock Analysis Report Allogene Therapeutics, Inc. (ALLO): Free Stock Analysis Report Chemomab Therapeutics Ltd. Sponsored ADR (CMMB): Free Stock Analysis ReportThis article originally published on Zacks Investment Research (zacks.com).Zacks Investment ResearchWeiter zum vollständigen Artikel bei Zacks Weiter zum vollständigen Artikel bei Zacks