Revolution Medicines Posts Wider-Than-Expected Loss in Q3, Sales Nil

Revolution Medicines RVMD reported a third-quarter 2025 loss of $1.61 per share, wider than the Zacks Consensus Estimate of a loss of $1.39. The company had incurred a loss of 94 cents in the year-ago quarter. Currently, Revolution Medicines does not have any approved products in its portfolio. Hence, it has yet to generate revenues.Year to date, shares of RVMD have surged 36% compared with the industry’s 10% growth.More on RVMD’s EarningsResearch and development expenses amounted to around $263 million, up 73% year over year. This significant increase was primarily driven by higher costs associated with clinical studies and manufacturing for the company’s drug candidates, as well as increased employee-related expenses.General and administrative expenses amounted to nearly $53 million, up 120% year over year, mainly due to higher employee-related expenses incurred during the quarter.As of Sept. 30, 2025, Revolution Medicines had cash, cash equivalents and short-term investments worth $1.9 billion compared with $2.1 billion as of June 30, 2025.2025 GuidanceThe company reiterated its guidance for operating expenses for the full year. It expects the figure to be between $1.03 billion and $1.09 billion, which includes non-cash stock-based compensation expense of $115-$130 million.RVMD’s Pipeline UpdatesRevolution Medicines is developing multiple novel drugs that target the active, GTP-bound form (or ON form) of RAS proteins, which the company refers to as RAS(ON). Its lead pipeline drug is daraxonrasib, an investigational oral RAS(ON) multi-selective inhibitor designed to target all three major RAS mutation hotspot positions (G12, G13 and Q61).RVMD is currently evaluating daraxonrasib across two late-stage registrational studies — RASolve 301 and RASolute 302. While the RASolve 301 study is evaluating the drug in patients with locally advanced or metastatic RAS-mutated NSCLC, RASolute 302 is assessing its efficacy for second-line metastatic PDAC. A data readout from the RASolute 302 study is expected in 2026.The company is also expanding the development of daraxonrasib in the first-line setting across both NSCLC and PDAC indications. While the study on first-line PDAC is on track to start before the end of 2025, the NSCLC study is expected to begin in 2026. Revolution recently initiated the phase III RASolute 304 study on the drug as an adjuvant therapy for patients with resectable PDAC.While multi-selective inhibitors like daraxonrasib target several forms of RAS mutations, Revolution Medicines is also developing mutant-selective inhibitors like elironrasib (targeting G12C) and zoldonrasib (for G12D) that are designed to suppress the growth of specific RAS-bearing cancer cells. The company is pursuing an expansive combination strategy to enhance efficacy and broaden therapeutic reach, especially in first-line settings.RVMD is on track to start a registrational study, evaluating a combination therapy involving zoldonrasib in first-line metastatic PDAC, in the first half of 2026. It also intends to start one or more pivotal combination studies incorporating either elironrasib or zoldonrasib next year.RVMD’s Zacks RankRevolution currently carries a Zacks Rank #3 (Hold).Revolution Medicines, Inc. Price  Revolution Medicines, Inc. price | Revolution Medicines, Inc. QuoteOur Key Picks Among Biotech StocksSome better-ranked stocks from the sector are Alkermes ALKS, CorMedix CRMD and ANI Pharmaceuticals ANIP. While ALKS and CRMD each sport a Zacks Rank #1 (Strong Buy) at present, ANIP carries a Zacks Rank #2 (Buy). You can see the complete list of today’s Zacks #1 Rank stocks here.EPS estimates for Alkermes’ 2025 have increased from $1.78 to $1.96, while those for 2026 have risen from $1.69 to $1.77 in the past 60 days. ALKS stock has gained 8% year to date.Alkermes’ earnings beat estimates in three of the trailing four quarters and missed the mark on one occasion, delivering an average negative surprise of 4.58%.In the past 60 days, estimates for CorMedix’s earnings per share (EPS) have increased from $1.24 to $1.85 for 2025. During the same time, EPS estimates for 2026 have increased from $2.09 to $2.49. Year to date, shares of CRMD have rallied 38%.CorMedix’s earnings beat estimates in each of the trailing four quarters, the average surprise being 34.85%.In the past 60 days, estimates for ANI Pharmaceuticals’ EPS have increased from $7.25 to $7.29 for 2025. During the same time, EPS estimates for 2026 have increased from $7.74 to $7.81. Year to date, shares of ANIP have surged 68%.ANI Pharmaceuticals' earnings beat estimates in each of the trailing four quarters, the average surprise being 22.66%.Zacks' Research Chief Names "Stock Most Likely to Double"Our team of experts has just released the 5 stocks with the greatest probability of gaining +100% or more in the coming months. Of those 5, Director of Research Sheraz Mian highlights the one stock set to climb highest.This top pick is a little-known satellite-based communications firm. Space is projected to become a trillion dollar industry, and this company's customer base is growing fast. Analysts have forecasted a major revenue breakout in 2025. Of course, all our elite picks aren't winners but this one could far surpass earlier Zacks' Stocks Set to Double like Hims & Hers Health, which shot up +209%.Free: See Our Top Stock And 4 Runners UpWant the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Alkermes plc (ALKS): Free Stock Analysis Report ANI Pharmaceuticals, Inc. (ANIP): Free Stock Analysis Report CorMedix Inc (CRMD): Free Stock Analysis Report Revolution Medicines, Inc. (RVMD): Free Stock Analysis ReportThis article originally published on Zacks Investment Research (zacks.com).Zacks Investment ResearchWeiter zum vollständigen Artikel bei Zacks Weiter zum vollständigen Artikel bei Zacks